解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract:AIMS/HYPOTHESIS:While it is well known that diet-induced obesity causes insulin resistance, the precise mechanisms underpinning the initiation of insulin resistance are unclear. To determine factors that may cause insulin resistance, we have performed a detailed time-course study in mice fed a high-fat diet (HFD). MET...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-013-2913-1
更新日期:2013-07-01 00:00:00
abstract:AIMS/HYPOTHESIS:Monogenic diabetes (MD) might be misdiagnosed as type 1 diabetes. The prevalence of MD among children with apparent type 1 diabetes has not been established. Our aim was to estimate the prevalence of common forms of MD in childhood diabetes. METHODS:We investigated 2,756 children aged 0-14 years with n...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-013-2916-y
更新日期:2013-07-01 00:00:00
abstract:AIMS/HYPOTHESIS:Beta cells situated in the islet of Langerhans respond more vigorously to glucose than do dissociated beta cells. Mechanisms for this discrepancy were studied by comparing insulin-producing MIN6 cells aggregated into pseudoislets with MIN6 monolayer cells and mouse and human islets. METHODS:MIN6 monola...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-013-2903-3
更新日期:2013-07-01 00:00:00
abstract:AIMS/HYPOTHESIS:Proinsulin is possibly associated with cancer through activation of insulin receptor isoform A. We sought to investigate the associations between proinsulin and 20 year cancer mortality rates. METHODS:The study was performed within the Hoorn Study, a population-based study of glucose metabolism in indi...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-013-2864-6
更新日期:2013-05-01 00:00:00
abstract:AIMS/HYPOTHESIS:Enterovirus (e.g. Coxsackie B virus serotypes [CVBs]) infections may be associated with development of type 1 diabetes. Studies conducted in several European countries have, however, shown an inverse correlation between the incidence of type 1 diabetes and the prevalence of enterovirus infections. These...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-013-2834-z
更新日期:2013-04-01 00:00:00
abstract:AIMS/HYPOTHESIS:A reduction in retinal blood flow occurs early in diabetes and is likely to be involved in the development of diabetic retinopathy. We hypothesise that activation of the arginase pathway could have a role in the vascular dysfunction of diabetic retinopathy. METHODS:Experiments were performed using a mo...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-012-2789-5
更新日期:2013-03-01 00:00:00
abstract:AIMS/HYPOTHESIS:The paucity of information on the epigenetic barriers that are blocking reprogramming protocols, and on what makes a beta cell unique, has hampered efforts to develop novel beta cell sources. Here, we aimed to identify enhancers in pancreatic islets, to understand their developmental ontologies, and to ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-012-2797-5
更新日期:2013-03-01 00:00:00
abstract:AIMS/HYPOTHESIS:A key morphological feature of diabetic nephropathy is the accumulation and deposition of glycogen in renal tubular cells, known as Armanni-Ebstein lesions. While this observation has been consistently reported for many years, the molecular basis of these lesions remains unclear. METHODS:Using biochemi...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-012-2805-9
更新日期:2013-03-01 00:00:00
abstract:AIMS/HYPOTHESIS:Fenofibrate is a drug used to treat hyperlipidaemia that works by inhibiting hepatic triacylglycerol synthesis. Sterol regulatory element binding protein-1c (SREBP-1c) is a major regulator of the expression of genes involved in hepatic triacylglycerol synthesis. In addition, endoplasmic reticulum (ER)-b...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-012-2771-2
更新日期:2013-02-01 00:00:00
abstract:AIMS/HYPOTHESIS:Type 2 diabetes mellitus is associated with reduced incretin effects. Although previous studies have shown that hyperglycaemia contributes to impaired incretin responses in beta cells, it is largely unknown how hyperlipidaemia, another feature of type 2 diabetes, contributes to impaired glucagon-like pe...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-012-2776-x
更新日期:2013-02-01 00:00:00
abstract:AIMS/HYPOTHESIS:Pancreatic islet transplantation (PIT) offers a physiological treatment for type 1 diabetes, but the failure of islet engraftment hinders its application. The female hormone 17β-oestradiol (E2) favours islet survival and stimulates angiogenesis, raising the possibility that E2 may enhance islet engraftm...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-012-2764-1
更新日期:2013-02-01 00:00:00
abstract:AIMS/HYPOTHESIS:The main objective of this work was to discover new drugs that can activate the differentiation of multipotent pancreatic progenitors into endocrine cells. METHODS:In vitro experiments were performed using fetal pancreatic explants from rats and mice. In this assay, we examined the actions on pancreati...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-012-2778-8
更新日期:2013-02-01 00:00:00
abstract:AIMS/HYPOTHESIS:Glucagon-like peptide-1 (GLP-1) lowers glucose levels by potentiating glucose-induced insulin secretion and inhibiting glucagon release. The question of whether GLP-1 exerts direct effects on the liver, independently of the hormonal changes, is controversial. We tested whether an exogenous GLP-1 infusio...
journal_title:Diabetologia
pub_type: 临床试验,杂志文章
doi:10.1007/s00125-012-2738-3
更新日期:2013-01-01 00:00:00
abstract:AIMS/HYPOTHESIS:Insulin clearance may decline as an early mechanism compensating for deteriorating insulin sensitivity. However, no previous studies have investigated the association between subclinical inflammation or impaired fibrinolysis and insulin clearance. We examined the association between plasminogen activato...
journal_title:Diabetologia
pub_type: 杂志文章,多中心研究
doi:10.1007/s00125-012-2741-8
更新日期:2013-01-01 00:00:00
abstract:AIMS/HYPOTHESIS:Sympathetic nerves influence islet hormone levels in the circulation. Insights into islet sympathetic innervation and its remodelling in diabetes may impact future therapeutics. However, standard immunohistochemistry and microtome-based microscopy cannot provide an integral view of the islet neurovascul...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-012-2699-6
更新日期:2012-12-01 00:00:00
abstract:AIMS/HYPOTHESIS:Human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hIPSCs) offer unique opportunities for regenerative medicine and for the study of mammalian development. However, developing methods to differentiate hESCs/hIPSCs into specific cell types following a natural pathway of developm...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-012-2687-x
更新日期:2012-12-01 00:00:00
abstract:AIMS/HYPOTHESIS:To investigate clinical and sociodemographic predictors of birthweight in singletons born to women with type 1 or type 2 diabetes. METHODS:Normally formed singleton live births and intrapartum stillbirths, born to women with pre-conception diabetes during 1996-2008, were identified from the population-...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-012-2721-z
更新日期:2012-12-01 00:00:00
abstract:AIMS/HYPOTHESIS:Acute hyperglycaemia rapidly suppresses endogenous glucose production (EGP) in non-diabetic individuals, mainly by inhibiting glycogenolysis. Loss of this 'glucose effectiveness' contributes to fasting hyperglycaemia in type 2 diabetes. Elevated NEFA levels characteristic of type 2 diabetes impair gluco...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-012-2662-6
更新日期:2012-11-01 00:00:00
abstract:AIMS/HYPOTHESIS:The aim of this study was to determine whether oral dosing with N-acetylcysteine (NAC) increases intraplatelet levels of the antioxidant, glutathione (GSH), and reduces platelet-monocyte conjugation in blood from patients with type 2 diabetes. METHODS:In this placebo-controlled randomised crossover stu...
journal_title:Diabetologia
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00125-012-2685-z
更新日期:2012-11-01 00:00:00
abstract:AIMS/OBJECTIVE:Nephropathy, a major complication of diabetes, is the leading cause of end-stage renal disease. Recent studies have demonstrated that podocyte injury is involved in the onset of and progression to renal insufficiency. Here, we describe a novel, highly sensitive ELISA for detecting urinary podocalyxin, a ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-012-2661-7
更新日期:2012-11-01 00:00:00
abstract:AIMS/HYPOTHESIS:Few data are available about intakes and food sources of trans-fatty acids (TFAs) or their associations with cardiometabolic outcomes in Asian people who consume a prudent diet but are experiencing rapid nutritional transitions. We aimed to investigate the relationships between TFA biomarkers and type 2...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-012-2674-2
更新日期:2012-11-01 00:00:00
abstract::The insulin receptor substrate proteins IRS1 and IRS2 are key targets of the insulin receptor tyrosine kinase and are required for hormonal control of metabolism. Tissues from insulin-resistant and diabetic humans exhibit defects in IRS-dependent signalling, implicating their dysregulation in the initiation and progre...
journal_title:Diabetologia
pub_type: 杂志文章,评审
doi:10.1007/s00125-012-2644-8
更新日期:2012-10-01 00:00:00
abstract::It is hoped that information garnered from studies on population genetics will one day be translated into a form in which it meaningfully improves the prediction, prevention or treatment of type 2 diabetes. Type 2 diabetes genetics researchers have made extraordinary progress in identifying common genetic variants tha...
journal_title:Diabetologia
pub_type: 评论,杂志文章
doi:10.1007/s00125-012-2683-1
更新日期:2012-10-01 00:00:00
abstract:AIMS/HYPOTHESIS:Activation of the G protein-coupled receptor (GPR)40 by long-chain fatty acids potentiates glucose-stimulated insulin secretion (GSIS) from pancreatic beta cells, and GPR40 agonists are in clinical development for type 2 diabetes therapy. GPR40 couples to the G protein subunit Gα(q/11) but the signallin...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-012-2650-x
更新日期:2012-10-01 00:00:00
abstract:AIMS/HYPOTHESIS:Reactive oxygen species (ROS) contribute to diabetes-induced glomerular injury and endoplasmic reticulum (ER) stress-induced beta cell dysfunction, but the source of ROS has not been fully elucidated. Our aim was to determine whether p47(phox)-dependent activation of NADPH oxidase is responsible for hyp...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-012-2586-1
更新日期:2012-09-01 00:00:00
abstract:AIMS:The gene SLC2A2 encodes GLUT2, which is found predominantly in pancreas, liver, kidney and intestine. In mice, GLUT2 is the major glucose transporter into pancreatic beta cells, and biallelic Slc2a2 inactivation causes lethal neonatal diabetes. The role of GLUT2 in human beta cells is controversial, and biallelic ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-012-2595-0
更新日期:2012-09-01 00:00:00
abstract:AIMS/HYPOTHESIS:The study aimed to assess, in multiple populations, the role of HLA alleles on early and late age at onset of type 1 diabetes. METHODS:Stepwise linear regression models were used to determine which HLA class I and class II risk alleles to include. High-resolution genotyping data for patients from the T...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-012-2608-z
更新日期:2012-09-01 00:00:00
abstract:AIMS/HYPOTHESIS:In early type 1 diabetes mellitus, renal salt handling is dysregulated, so that the glomerular filtration rate becomes inversely proportional to salt intake. The salt paradox occurs in both humans and rats and, with low salt intake, results in diabetic hyperfiltration. We tested whether increased salt i...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-012-2569-2
更新日期:2012-08-01 00:00:00
abstract:AIMS/HYPOTHESIS:The receptor tyrosine kinase, c-Kit, and its ligand, stem cell factor, control a variety of cellular processes, including pancreatic beta cell survival and differentiation as revealed in c-Kit ( Wv ) mice, which have a p...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-012-2566-5
更新日期:2012-08-01 00:00:00
abstract:AIMS/HYPOTHESIS:Hyperlipidaemia is an independent risk factor for the progression of diabetic nephropathy, but its molecular mechanism remains elusive. We investigated in mice how diabetes and hyperlipidaemia cause renal lesions separately and in combination, and the involvement of Toll-like receptor 4 (TLR4) in the pr...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-012-2578-1
更新日期:2012-08-01 00:00:00
abstract:AIMS/HYPOTHESIS:Somatostatin from islet delta cells inhibits insulin and glucagon secretion, but knowledge of the regulation of pancreatic somatostatin release is limited. Some insulin secretagogues stimulate somatostatin secretion, and here we investigated whether delta cell secretory responses are indirectly regulate...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-012-2546-9
更新日期:2012-07-01 00:00:00
abstract:AIMS/HYPOTHESIS:Increased NEFA levels, characteristic of type 2 diabetes mellitus, contribute to skeletal muscle insulin resistance. While NEFA-induced insulin resistance was formerly attributed to decreased glycolysis, it is likely that glucose transport is the rate-limiting defect. Recently, the plant-derived sugar a...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-012-2527-z
更新日期:2012-06-01 00:00:00
abstract:AIMS/HYPOTHESIS:Vitamin D deficiency may increase the risk of type 2 diabetes. We therefore investigated whether serum concentrations of 25-hydroxyvitamin D [25(OH)D] would predict the development of prediabetes (impaired fasting glucose, impaired glucose tolerance or the two combined) and type 2 diabetes, either on th...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-012-2529-x
更新日期:2012-06-01 00:00:00
abstract:AIMS/HYPOTHESIS:Soluble CD163 (sCD163) was recently identified as a strong risk marker for developing type 2 diabetes. We hypothesised that sCD163 independently associates with insulin resistance. METHODS:This cross-sectional study includes 234 participants: 96 with type 2 diabetes, 34 with impaired glucose tolerance ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-012-2533-1
更新日期:2012-06-01 00:00:00
abstract:AIMS/HYPOTHESIS:This study was aimed at the elucidation of the pathogenesis of glucotoxicity, i.e. the mechanism whereby hyperglycaemia damages pancreatic beta cells. The identification of pathways in the process may help identify targets for beta cell-protective therapy. Carbohydrate response element-binding protein (...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-012-2506-4
更新日期:2012-06-01 00:00:00
abstract::There is now evidence that a single bout of endurance (aerobic) or resistance exercise reduces 24 h post-exercise subcutaneous glucose profiles to the same extent in insulin-resistant humans with or without type 2 diabetes. However, it remains to be determined which group would benefit most from specific exercise prot...
journal_title:Diabetologia
pub_type: 评论,杂志文章
doi:10.1007/s00125-012-2513-5
更新日期:2012-05-01 00:00:00
abstract:AIMS/HYPOTHESIS:Cardiovascular events and death are better predicted by postprandial glucose (PPG) than by fasting blood glucose or HbA(1c). While chronic exercise reduces HbA(1c) in patients with type 2 diabetes, short-term exercise improves measures of insulin sensitivity but does not consistently alter responses to ...
journal_title:Diabetologia
pub_type: 临床试验,杂志文章
doi:10.1007/s00125-012-2490-8
更新日期:2012-05-01 00:00:00
abstract::AMP-activated protein kinase (AMPK) serves as a major regulator of energy homeostasis and is activated by different glucose-lowering agents. Indeed, AMPK has been identified as an attractive target for the development of innovative molecules to treat type 2 diabetes. In this issue of Diabetologia (doi: ...
journal_title:Diabetologia
pub_type: 评论,杂志文章
doi:10.1007/s00125-012-2503-7
更新日期:2012-05-01 00:00:00
abstract:AIMS/HYPOTHESIS:B-type natriuretic peptide (BNP) is a hormone released from cardiomyocytes in response to cell stretching and elevated in heart failure. Recent observations indicate a distinct connection between chronic heart failure and diabetes mellitus. This study investigated the role of BNP on glucose metabolism. ...
journal_title:Diabetologia
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00125-011-2392-1
更新日期:2012-05-01 00:00:00
abstract:AIMS/HYPOTHESIS:Serum potassium has been found to be a significant predictor of diabetes risk, but the effect of dietary potassium on diabetes risk is not clear. We sought to determine if dietary potassium is associated with risk of incident type 2 diabetes in young adults. METHODS:We used data from the Coronary Arter...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-012-2487-3
更新日期:2012-05-01 00:00:00